An efficient one-pot multicomponent, Amberlite IR120(H) catalyzed microwave-assisted synthesis of 1,2,4,5-tetrasubstituted-1H-imidazoles: Plausible mechanism and antibacterial evaluation

Abstract

The present study describes an efficient and convenient one-pot multicomponent, microwave-assisted synthesis of polysubstituted-1H-imidazoles in good yields under mild reaction conditions. The procedure uses inexpensive, nontoxic, and reusable Amberlite IR120(H) as a catalyst. The new method exhibits a broad tolerance for diverse structural moieties, thereby demonstrating the robustness and applicability of the synthetic method. Further synthesized polysubstituted-1H-imidazoles exhibited moderate to good activity against bacterial strains under study.

Graphical Abstract

Keywords:

• One-pot
• multicomponent
• microwave-assisted
• amberlite IR120(H)
• mechanism
• antibacterial activity

Disclosure statement

The authors declare that there is no conflict of interest regarding the publication of this article.