Synthesis of Bis(indolyl) Methanes in Catalyst- and Solvent-Free Reaction

Abstract

Efficient synthesis of bis(indolyl) methanes by the reaction of indoles with various carbonyl compounds in the absence of catalyst and solvent afforded the corresponding bis(indolyl) methanes in excellent yields.

Keywords:

• Aldehydes
• bis(indolyl) methanes
• indole
• solvent-free

ACKNOWLEDGMENT

The authors acknowledge partial support of this work by Prof. B. P. Bandgar, vice chancellor, University of Solapur, India.

Notes

^a The substrate was treated with indole (4 mmol) by stirring at 80 °C in absence of solvent.

^b All products were identified by their IR and ¹H NMR spectra.

^c Isolated yields after column chromatography.