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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2011 - Issue 8
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Original Articles

Asymmetric Synthesis of (S,S,S)-2-Aza-bicyclo-[3.3.0]-octane-3-carboxylic Acid Benzyl Ester: Formal Synthesis of Ramipril

G. C. M. Kondaiah Center of Excellence, IPDO, Dr. Reddy's Laboratories Ltd., Bachupalli, Qutubullapur, Andhra Pradesh, India
,
M. Vivekanandareddy Department of Chemistry, Yeshwant Mahavidhyalaya, Nanded, Maharashtra, India
,
L. Amarnath Reddy Center of Excellence, IPDO, Dr. Reddy's Laboratories Ltd., Bachupalli, Qutubullapur, Andhra Pradesh, India
,
Smita V. Anurkar Department of Chemistry, Yeshwant Mahavidhyalaya, Nanded, Maharashtra, India
,
V. M. Gurav Department of Chemistry, Yeshwant Mahavidhyalaya, Nanded, Maharashtra, India
,
M. Ravikumar Center of Excellence, IPDO, Dr. Reddy's Laboratories Ltd., Bachupalli, Qutubullapur, Andhra Pradesh, India
,
Apurba Bhattacharya Center of Excellence, IPDO, Dr. Reddy's Laboratories Ltd., Bachupalli, Qutubullapur, Andhra Pradesh, India
&
Rakeshwar Bandichhor Center of Excellence, IPDO, Dr. Reddy's Laboratories Ltd., Bachupalli, Qutubullapur, Andhra Pradesh, IndiaCorrespondence[email protected]
 show all
Pages 1186-1191 | Received 02 Jan 2010, Published online: 21 Mar 2011
 
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Abstract

An asymmetric synthesis of (S,S,S)-2-aza-bicyclo-[3.3.0]-octane-3-carboxylic acid benzyl ester 2 as an intermediate of angiotensin converting enzyme (ACE) inhibitor, ramipril 1, is described.

ACKNOWLEDGMENTS

We greatly appreciate Prof. Dieter Enders for his promptness in sharing documents related to SAMP. We are also thankful to the management of Dr. Reddy's Laboratories Ltd. for supporting this work.

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