Expression and induction of CYP1A1/1A2, CYP2A6 and CYP3A4 in primary cultures of human hepatocytes: a 10-year follow-up

V. Meunier Sanofi Recherche, Department of Preclinical Metabolism and Pharmacokinetics, 371 Rue du Professeur Joseph Blayac, F-34184 Montpellier, Cedex 4, France

M. Bourrie Sanofi Recherche, Department of Preclinical Metabolism and Pharmacokinetics, 371 Rue du Professeur Joseph Blayac, F-34184 Montpellier, Cedex 4, France

B. Julian Sanofi Recherche, Department of Preclinical Metabolism and Pharmacokinetics, 371 Rue du Professeur Joseph Blayac, F-34184 Montpellier, Cedex 4, France

E. Marti Sanofi Recherche, Department of Preclinical Metabolism and Pharmacokinetics, 371 Rue du Professeur Joseph Blayac, F-34184 Montpellier, Cedex 4, France

F. Guillou Sanofi Recherche, Department of Preclinical Metabolism and Pharmacokinetics, 371 Rue du Professeur Joseph Blayac, F-34184 Montpellier, Cedex 4, France

Y. Berger Sanofi Recherche, Department of Preclinical Metabolism and Pharmacokinetics, 371 Rue du Professeur Joseph Blayac, F-34184 Montpellier, Cedex 4, France

G. Fabre Sanofi Recherche, Department of Preclinical Metabolism and Pharmacokinetics, 371 Rue du Professeur Joseph Blayac, F-34184 Montpellier, Cedex 4, France

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Abstract

1. The aims were to refine experimental conditions (using 76 human hepatocyte preparations) in terms of the selection of enzyme inducers and their optimal concentration, the treatment duration with inducers and the choice of specific cytochrome P450 isoform(s) probes to optimize the use of primary hepatocytes for predicting the potential induction by new chemical entities of cytochrome P450 isoforms in vivo

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Expression and induction of CYP1A1/1A2, CYP2A6 and CYP3A4 in primary cultures of human hepatocytes: a 10-year follow-up

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Expression and induction of CYP1A1/1A2, CYP2A6 and CYP3A4 in primary cultures of human hepatocytes: a 10-year follow-up

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