Preliminary investigation of a multimodal enhanced brain function index among high school and collegiate concussed male and female athletes

ABSTRACT

Objective: The primary purpose of this study was to examine the longitudinal effects of sports-related concussion (SRC) on a multi-faceted assessment battery which included neuropsychological testing, symptom reporting, and enhanced brain function index (eBFI) among athletes with and without SRC. A secondary purpose was to explore longitudinal sex differences among these measures in athletes with and without SRC.

Methods: A case-control, repeated-measures design was used for this study. A total of 186 athletes (concussed group:n= 87 controls:n= 99) participated in the study. A repeated-measures design was used in which each athlete was tested at four time points following an SRC: within 72 h of injury (Day 0; 2.0 ± 0.9 days following injury), 5 days following injury (Day 5; 5.0 ± 0.0), at return to play (RTP; 18.3 ± 13.8 days following injury), and within 45 days following RTP (RTP45; 66.2 ± 19.0 days following injury). All analyses were conducted separately using a 2 (Group: concussed, control) × 2 (Sex: male, female) × 4 (Time:Day 0, Day 5, RTP, RTP45) univariate multi-level model including the random intercept for each participant. A higher eBFI score indicates a better performance. Alpha level was set aprior at .05. This study was registered on clinicaltrials.gov (Objective Brain Function Assessment of mTBI/Concussion in College/high school Athletes NCT02477943, NCT02661633, CAS 13–25 NCT03963804).

Results: Concussed athletes exhibited impaired eBFI within 72 h of SRC and at Day 5 compared to controls (p<.001). Analysis of eBFI scores between male and female athletes revealed a main effect of sex (p=.05), with female athletes exhibiting lower eBFI (33.9 ± 30.7) relative to male athletes (40.4 ± 33.0), however, it did not indicate interactions between sex, group, and time (p’s ≥ 0.786).

Conclusion: The eBFI appears to be a useful tool in determining concussed athletes during the acute stages of an SRC. However, this index may lack the sensitivity to detect sex-related differences between groups at various time points during recovery.

KEYWORDS:

• eBFI
• sex differences
• concussion
• SCAT

Acknowledgement

This study was funded in part by a contract to BrainScope Company Inc. from the U.S. Navy (Naval Health Research Center) contract # W911QY-14-C-0098.

Declaration of interest

Dr. Elbin served as a consultant for BrainScope, Inc.

Additional information

Funding

The clinical study was funded in part by a contract to BrainScopeCompany Inc. from the U.S. Navy (Naval Health Research Center), contract #W911QY-14-C-0098. Disclaimer: The views, opinions and/orfindings contained in this report are those of the author(s) and shouldnot be construed as an official Department of the Navy position, policyor decision unless so designated by other documentation.