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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 64, 2015 - Issue 14
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Original Articles

Biocompatible Polymer Coated Paramagnetic Nanoparticles for Doxorubicin Delivery: Synthesis and Anticancer Effects Against Human Breast Cancer Cells

Mina ZarouniSchool of Advanced Medical Science, Tabriz (Aras) University of Medical Sciences, Tabriz, Iran
,
Roya SalehiSchool of Advanced Medical Science, Tabriz (Aras) University of Medical Sciences, Tabriz, Iran;Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran
,
Abolfazl AkbarzadehSchool of Advanced Medical Science, Tabriz (Aras) University of Medical Sciences, Tabriz, Iran
,
Nasser SamadiSchool of Advanced Medical Science, Tabriz (Aras) University of Medical Sciences, Tabriz, Iran;Department of Biochemistry and Clinical Laboratories, Faculty of Medical Sciences, Tabriz University of Medical Sciences, Tabriz, IranCorrespondence[email protected]
,
Soodabeh DavaranResearch Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, ,Correspondence[email protected]
,
Fatemeh RamezaniSchool of Advanced Medical Science, Tabriz (Aras) University of Medical Sciences, Tabriz, Iran
&
Hassan DariushnejadSchool of Advanced Medical Science, Tabriz (Aras) University of Medical Sciences, Tabriz, Iran
 show all
Pages 718-726 | Received 29 Aug 2014, Accepted 21 Dec 2014, Published online: 08 Apr 2015
 
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Abstract

To increase the efficacy of doxorubicin in induction of apoptosis, pH-responsive nanocarriers with an average particle size of 20 nm by using chitosan-polymethacrylic acid (CTS-PMAA) shells and Fe3O4 cores via in situ polymerization approach were synthesized. Doxorubicin hydrochloride (DOX) was loaded effectively to nanocarrier through electrostatic interactions and strong hydrogen banding. The cumulative release of DOX-loaded nanoparticles was pH dependent with a maximum release rate at pH 5.8. In vitro cytotoxicity assay revealed the biocompatibility of blank nanocarrier and superior anticancer performance of DOX-loaded nanoparticles verified by DAPI staining and MTT assay tests.

GRAPHICAL ABSTRACT

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