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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 66, 2017 - Issue 12
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Original Articles

Synthesis strategies for optimizing sizes of PLGA nanoparticles containing recombinant Chenopodium album (rChe a 3) allergen

Jafar HajaviStudent Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran;Immunology Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
,
Mojtaba SankianImmunology Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
,
Abdol-Reza VarastehAllergy Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
&
Maryam HashemiNanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranCorrespondence[email protected]
Pages 603-608 | Received 17 Jul 2016, Accepted 20 Oct 2016, Published online: 04 May 2017
 
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ABSTRACT

The size of antigen delivery systems impact on the immune induction. The purpose of this study was to obtain poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) containing rChe a 3 allergen in different sizes (about 200, 400, and 800 nm). The optimal conditions were obtained by adjusting different parameters comprising molecular weight/concentration of polyvinyl alcohol, solvent type (dichloromethane or dichloromethane/acetone), sonication time, and addition of cryoprotectant (sucrose). The optimized formulations were found to be stable for 60 days at 4°C. In conclusion, the preparation conditions need to be adjusted to obtain allergen-PLGA NPs with specific aforementioned sizes.

GRAPHICAL ABSTRACT

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