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The American Journal of Drug and Alcohol Abuse
Encompassing All Addictive Disorders
Volume 34, 2008 - Issue 4
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The Effects of Levetiracetam on Alcohol Consumption in Alcohol-Dependent Subjects: An Open Label Study

Ofra Sarid-Segal Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA
,
Joanna Piechniczek-Buczek Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA
,
Clifford Knapp Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA
,
Maryam Afshar Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA
,
Eric Devine Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA
,
Laurie Sickles Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA
,
Emma Uwodukunda Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA
,
Courtney Richambault Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA
,
Jillian Koplow Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA
&
Domenic Ciraulo Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA
 show all
Pages 441-447 | Published online: 07 Jul 2009
 
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Abstract

The aim of this open-label pilot study was to assess the efficacy and safety of the novel anticonvulsant agent, levetiracetam, for the treatment of alcohol dependence. A maximal dose of 2000 mg was administered daily for 10 weeks to alcohol dependent subjects (n = 20). Mean reported ethanol intake declined significantly from 5.3 to 1.7 standard drinks per day. Levetiracetam was well tolerated by most subjects.

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