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Abstract
New mononuclear Ru(II) complexes [Ru(A)2(B)]2+, where A = 2,2′-bipyridine/1,10-phenanthroline and B = 3,4,5-tri-OCH3-DPC, 4-CH3-DPC, 4-N(CH3)2-DPC, 4-NO2-DPC, N-BITSZ, PTSZ and PINH, were prepared and characterized by spectroscopic methods. The in vitro cytotoxic activities of the complexes and their corresponding ligands were investigated against the human cancer T-lymphocyte cell lines molt 4/c8 and CEM and the murine tumor leukemia cell line L1210, human promyelocytic leukemia cells (HL-60) and Bel-7402 liver cancer cells by MTT assay. The complexes [Ru(A)2(B)]2+ (A = 1,10-phenanthroline, B = 3,4,5-tri-OCH3-DPC) exerts rather more potent activities against all of these cell lines, especially for CEM and L1210. Ru complexes and structure–activity relationships and anticancer mechanisms are also discussed.
Acknowledgement
One of the authors Mrs. Srujana Vallala is thanking the Department of Science & Technology (DST), New Delhi, India, for providing the funds for carrying research (SR/WOS-A/LS-562/2011) dated 27/03/2012.