Synthesis and biological evaluation of Cu(II), Zn(II), and Ni(II) 3-(4-nitrophenyl)acrylic acid complexes with diamines as potential urease inhibitors

Abstract

Five new Cu(II), Zn(II), and Ni(II) 3-(4-nitrophenyl)acrylic acid complexes were synthesized and evaluated for inhibitory activity on jack bean urease. All five complexes were structurally determined by single crystal X-ray analysis. Compared with the positive reference acetohydroxamic acid (IC₅₀ = 13.25 μM), Cu(II) complexes 3 and 4 showed the strongest inhibitory activity against jack bean urease (IC₅₀ = 1.23 and 1.17 μM). Ni(II) and Zn(II) complexes also exhibited inhibitory activities (IC₅₀ = 10.09–13.10 μM).

Keywords:

• Urease inhibitor
• Cinnamate
• Transition metal complex
• Crystal structure

Supplementary material

Crystallographic data for the structural analysis has been deposited with the Cambridge Crystallographic Data Centre (CCDC 923178–923182 for 1–5). Copy of this information can be obtained free of charge from The Director, CCDC, 12 Union Road, Cambridge CB2 1EZ, UK (Fax: [phone]; E-mail: [email protected] or www: http://www.ccdc.cam.ac.uk).