Abstract
Three new complexes (1–3) have been synthesized and characterized by X-ray single crystal determination and evaluated for inhibitory activity on jack bean urease. All the complexes contained a new cinnamic acid derivative as the ligand (C11H12O4), (E)-3-(3,4-dimethoxyphenyl)acrylic acid, and crystallized in monoclinic C2/c space group. Complex 1 (C11H11O4)4(C3N2H8)2Cu2 (C3N2H8 = 1,2-diaminopropane) was obtained with a = 20.488(2), b = 19.596(2), c = 15.2500(13), β = 93.502(2)°, V = 6111.2(10) Å3, Z = 4, R 1 = 0.0616, and wR 2 = 0.2059. Complex 2 (C11H11O4)4(C3N2H8)2Cu2 (C3N2H8=1,3-diaminopropane) was obtained with a = 20.2494(12), b = 19.5732(12), c = 14.8940(8), β = 96.884(2)°, V = 5860.6(6) Å3, Z = 4, R 1 = 0.0409, and wR 2 = 0.1107. Complex 3 (C11H11O4)2(C2N2H6)2Ni2·H2O (C2N2H6 = ethylenediamine) was obtained with a = 28.359(2), b = 6.5422(5), c = 16.8587(14), β = 101.359(2)°, V = 3066.5(4) Å3, Z = 4, R 1 = 0.0422, and wR 2 = 0.1190. It was found that copper(II) complexes 1 [IC50 = 4.71 μM] and 2 [IC50 = 3.15 μM] showed strong inhibitory activity against jack bean urease compared with acetohydroxamic acid [IC50 = 10.01 μM] as a positive reference. Unfortunately, 3 exhibited no inhibitory activity.