Synthesis, solid-state structures, and urease inhibition activities of new copper(II) complexes based on O,N,O-tridentate Schiff bases

Abstract

Six new complexes of copper(II) coordinated with O,N,O-tridentate Schiff base dianions were synthesized and structurally characterized. The solid-state structures of 1–6 contain four-coordinate mononuclear copper(II) units with a slightly distorted square planar geometry. Complexes 1 and 4 derived from d-tyrosine have an infinite 1-D, right-handed helical chain, while 5 derived from l-tyrosine has an infinite 1-D, left-handed helical chain. Inhibitions of jack bean urease by 1–6 have been investigated, and potent inhibitory activities with IC₅₀ range of 2.15 ± 0.11–32.12 ± 0.65 μM have been observed for these copper(II) complexes. A docking analysis using a DOCK program was conducted to position 4 into the jack bean urease active site to determine the probable binding conformation.

Keywords:

• Copper(II) complexes
• X-ray structures
• urease inhibition
• molecular docking