Abstract
[CoIII(L1)2·H2O]NO3 (1), [MnII(L1)2·H2O] (2), and [ZnII(L1)2·H2O] (3) with a hydrazone derived from protocatechuic acid (HL1 = C15H13N3O3) were designed, synthesized, and characterized by C, H, N elemental analyses, single-crystal X-ray diffraction, and IR spectra, which revealed that the three complexes are similar structures. Docking study has been done. The urease inhibitory activities of the three complexes were tested. Complexes 1 and 3 showed strong inhibitory activity against jack bean urease with IC50 values of 45.9 and 11.64 μM. Complex 2 had no obvious inhibitory activity to urease; the IC50 was > 50 μM.
Acknowledgements
We thank the financial support from National Natural Science Foundation of China (Grant No. 31200090), Scientific Research Foundation for Returned Scholars, Ministry of Education of China, and National College Students’ Innovative and Entrepreneurial Training Plan of China (Grant No. 201410433033).