Potassium dichromate–induced changes on urinary-specific activities of gamma-glutamyl transpeptidase and alanine aminopeptidase enzymes

Abstract

It has been reported that potassium dichromate–induced nephrotoxicity is evidenced by diminution in creatinine clearance, increase in urinary protein, and structural damage to the proximal tubules. Damage to tissue often leads to the release of enzymes from the injured cells into the extracellular fluids. The aim of this study was to establish whether potassium dichromate induces changes in the urinary-specific activities of gamma-glutamyl transpeptidase and alanine aminopeptidase enzymes. Our results show that the administration of a single intraperitoneal dose of potassium dichromate decreased the activity of such enzymes in urine.

Keywords::

• Potassium dichromate
• Kidney
• Nephrotoxicity
• Alanine aminopeptidase
• Gamma-glutamyl transpeptidase

Acknowledgments

SLBT acknowledges support from the National Council of Science and Technology (CONACYT; México) in the form of an academic scholarship to carry out doctoral studies at the Universidad Autónoma de Aguascalientes.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.