Eucalyptol alleviates cisplatin-induced kidney damage in rats

Abstract

This study was aimed to explore the therapeutic effect of eucalyptol on cisplatin induced kidney damage in Wistar albino rats. The animals were divided into four groups: sham (S), eucalyptol (E), cisplatin (C), and cisplatin + eucalyptol (CE) randomly, six animals in each group. Groups C and CE were received cisplatin (12 mg/kg, a single dose, intraperitoneally (i.p.)). Groups E and CE were treated with eucalyptol (100 mg/kg, for seven days, orally). The blood samples and kidney tissues were collected following sacrification and analyzed histopathologically and biochemically. Histopathological results revealed tubular degeneration and necrosis, inflammatory cell infiltration, tubular lumen dilatation, enlargement of bowman’s space and hyaline cast were significantly irregular in the group C than group S. However, eucalyptol treatment (CE) modulated the alterations in the group C. Serum levels of blood urea nitrogen (BUN) and creatinine (CRE) were considerably higher in the group C compared to the other groups. There was no significant difference among the other groups statistically (except group C) in terms of BUN and CRE values. Eucalyptol treatment (at 100 mg/kg, for seven days) decreased the cisplatin induced increase in serum BUN and CRE levels and restored the reduced Vit C level and CAT activity of kidneys caused by cisplatin. Thus, eucalyptol’s antioxidative, nephroprotective, and curative effects indicated the potential for future drug development.

Keywords:

• Antioxidants
• cisplatin
• eucalyptol
• kidney
• nephrotoxicity

Author contributions

F. Kazak: conceptualized and designed the work; performed all laboratory experiments; analyzed and interpreted the data related to biochemistry; wrote the draft and final versions of the manuscript, and coordinated the peer review process. M. Z. Y. Deveci: conceptualized and designed the work; performed applications on experimental animals. G. Akçakavak: provided insight into the in vitro laboratory investigations; analyzed and interpreted the data related to pathology; wrote the draft of the manuscript. All authors read and approved the final version of the manuscript.

Disclosure statement

The authors declare no conflict of interest in this publication.

Data availability statement

All data required for the conduct of this study, and interpretation of results obtained from the experiments are included in this publication.

Additional information

Funding

None.