Article title: Effect of Curcumin on Lipid Profile, Fibrosis and Apoptosis in Liver Tissue in Abemaciclib-Administered Rats
Authors: Zübeyir Huyut, Bünyamin Uçar, Fikret ALTINDAĞ, Kenan Yıldızhan, Mehmet Tahir Huyut
Journal: Drug and Chemical Toxicology
DOI: https://doi.org/10.1080/01480545.2022.2135007
When the article has been previously published, the Statistical Analysis indicated is incorrect. Below is the correct version of the Statistical Analysis:
The statistical analysis was conducted with consideration for the differentiation of parameter and biomarker values due to experimental intervention, represented by effect size (Eta-η2). We performed a power analysis based on an effect size of 0.65 (as calculated with η2), alpha = 0.05, and power = 0.85, which determined a minimum total subject number of 40. While the normality of the data was checked with the Shapiro-Wilk test, the homogeneity of the population variances of the groups was examined with the Levene test. Since all biochemical parameters were normally distributed, mean and standard deviations were given for descriptive statistics.
The comparison of biochemical parameter levels between the control and experimental groups were conducted with Bootstrap one-way ANOVA linear contrast analysis, utilizing the simple sampling method and setting bootstrap performance according to 1000 samples. Then, differences between groups were examined with Tukey HSD or Games-Howell post-hoc tests.
Kruskal-Wallis analysis was used to analyze whether immunohistochemical studies differed between groups. Then, multiple comparisons between the immunohistochemical levels of the groups were examined with the Bonferroni adjusted Mann-Whitney U test.
The distributions of biochemical and immunohistochemical parameter measurement levels in the groups were summarized with histogram graphics, and the post-hoc results between the groups were shown with symbols in these graphics. Histogram plots were generated at the 95% confidence level, and error bars show a width of ±2 standard deviations. SPSS (version 26.0, SPSS Inc, Chicago) package program was used for statistical analysis of the data. Asymptotic significances (2-sided tests) are displayed. p < 0.05 was considered statistically significant.