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Publication Cover
Archives of Andrology
Journal of Reproductive Systems
Volume 53, 2007 - Issue 2
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Original

Regulation of Steroidogenesis by Cordyceps sinensis Mycelium Extracted Fractions with (hCG) Treatment in Mouse Leydig Cells

K. L. Wong Department of Anesthesia, Pain Management and Critical Care Medicine, China Medical University and Hospital, Taichung, Taiwan, ROC
,
E. Cheung So Department of Anesthesia, Chi-Mei Medical Center, Tainan, Taiwan, ROC; Institute of Basic Medical Science, National Cheng Kung University, Tainan, Taiwan, ROC
,
C. C. Chen Department of Anesthesia, Chi-Mei Medical Center, Tainan, Taiwan, ROC; Institute of Basic Medical Science, National Cheng Kung University, Tainan, Taiwan, ROC; Department of Cell Biology and Anatomy, National Cheng Kung University, Tainan, Taiwan, ROC
,
R. S. C. Wu Department of Anesthesia, Chi-Mei Medical Center, Tainan, Taiwan, ROC; Institute of Basic Medical Science, National Cheng Kung University, Tainan, Taiwan, ROC; Department of Cell Biology and Anatomy, National Cheng Kung University, Tainan, Taiwan, ROC
&
B.-M. Huang Department of Cell Biology and Anatomy, National Cheng Kung University, Tainan, Taiwan, ROCCorrespondence[email protected]
Pages 75-77 | Published online: 09 Jul 2009
 
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Abstract

The in vitro effect of extracted fractions of Cordyceps sinensis (CS) mycelium on hCG-treated testosterone production from purified normal mouse Leydig cells was examined. Different fractions extracted from CS (F1-water soluble polysaccharide, F2- water soluble protein and F3- poorly water soluble polysaccharide, and protein) were added to Leydig cells with hCG, and the production of testosterone was determined by radioimmunoassay (RIA). Testosterone productions stimulated by hCG in mouse Leydig cells were suppressed by F2 at 10 mg/ml and F3 at doses from 3 to 10 mg/ml, respectively. F2 and F3 at 10 mg/ml did inhibit dbcAMP-stimulated testosterone productions which indicated that F2 and F3 might affect steroidogenesis at the site after the formation of cyclic AMP. Finally, cycloheximide inhibited F2- and F3-treated mouse Leydig cell testosterone production.

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