225 intracranial aneurysms treated with the Low-profile Visualized Intraluminal Support (LVIS) stent: a single-center retrospective study

Abstract

Background For the treatment of intracranial aneurysms, the low-profile visualized intraluminal support (LVIS) stent is a new generation of highly visible-braided stent that was recently introduced in China. Here, we report our single-center retrospective experience of safety and efficacy utilizing LVIS for stent-assisted coiling of intracranial aneurysms.

Methods We included 218 patients with intracranial aneurysms consecutively treated with LVIS SR stents at our center in this study. Postoperative and follow-up embolization scores, procedural complications, clinical and angiographic findings at mid-term follow-up, as well as recurrence rate, preoperative and follow-up mRS scores were analyzed.

Results Two hundred and eighteen patients with two hundred and twenty five intracranial aneurysms were enrolled. The locations and distribution were ICA (125, 55.6%), PcomA (47, 20.9%), VA (38, 16.8%), and BA (15, 6.7%). Two hundred and eighteen aneurysms were treated with the stent-assisted coiling and seven patients with LVIS stents alone. Angiographic follow-up was available for 115 (51.1%) aneurysms, 8 (7.0%) of which had recurrences including 7 (6.5%) unruptured aneurysms and 1(14.3%) ruptured aneurysm. The procedural complication rate was 2.75% in total, including distal hemorrhage (1, 0.45%; SAH), ischemic events (5, 2.3%).

Conclusions Our single-center retrospective experience is one of the larger studies to date assessing the LVIS device. Compared with many laser-cut stent studies, the LVIS device had a higher aneurysm complete occlusion rate at follow-up coupled with low complication rates. However, this study was our initial experience with LVIS, larger patient numbers, and longer follow-up will be needed to fully assess the long-term efficacy of LVIS in treating intracranial aneurysms.

Keywords:

• Intracranial aneurysm
• low-profile stent
• stent-assisted coil
• Thromboembolism

Abbreviations:

• SAH: subarachnoid hemorrhage
• HBP: high blood pressure
• DM: diabetes mellitus
• SD: standard deviation
• mRS: modified Rankin Scale
• ADP: adenosine diphosphate
• AA: arachidonic acid
• CTA: computed tomography angiography
• DSA: digital subtract angiography
• MRA: magnetic resonance angiography
• IAs: intracranial aneurysms

Acknowledgments

We are grateful to Dr. Youxiang Li, Dr. Chuhan Jiang, Dr. Peng Jiang, Dr. Shiqing Mu, Dr. Xianli Lv, and Dr. Ming Lv for the endovascular treatment and data. Informed consent was obtained from the individual participant included in the study to publish related materials. Institutional review board approval was obtained from Beijing Tiantan Hospital’s ethics committee for this study.