Clinical Features and Prognostic Factors in Anti-Myelin Oligodendrocyte Glycoprotein Antibody Positive Optic Neuritis

ABSTRACT

In order to review the clinical features of anti-myelin oligodendrocyte glycoprotein antibody positive optic neuritis (MOGON), we investigated the clinical characteristics, visual function, optical coherence tomography findings, and magnetic resonance imaging of 31 patients (44 eyes). MOGON was more common in middle age without sex difference and was characterised by pain on eye movement and optic disc swelling. Magnetic resonance imaging lesions tended to be long with inflammation around the optic nerve sheath; longer lesions were associated with worse visual acuities at onset. Recurrence was significantly associated with retinal nerve fibre layer thinning, and thus, it is important to reduce recurrence as much as possible.

KEYWORDS:

• Anti-myelin oligodendrocyte glycoprotein antibody
• optic neuritis
• recurrent optic neuritis
• optical coherence tomography
• magnetic resonance imaging

Disclosure statement

Toshiyuki, T received research grants from Cosmic Corporation Co Ltd. and Medical & Biological Laboratories CO Ltd.

Data availability statement

All data generated or analysed during this study are included in this article. Further enquiries can be directed to the corresponding author.

Statement of ethics

The research has been complied with all the relevant national regulations, and institutional policies and in accordance with the tenets of the Helsinki Declaration and has been approved by the Inouye Eye Hospital’s institutional review board (202307–5). Informed consent was obtained as an opt-out on the website, allowing the participants to refuse participation in the study at any time.

Additional information

Funding

The authors reported there is no funding associated with the work featured in this article.