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Journal of Neurogenetics Volume 19, 2005 - Issue 2
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ISOGENIC AUTOSOMES TO BE APPLIED IN OPTIMAL SCREENING FOR NOVEL MUTANTS WITH VIABLE PHENOTYPES IN DROSOPHILA MELANOGASTER

Punita Sharma Department of Genetics, University of Cambridge, Cambridge, UK
,
Zoltan Asztalos Department of Genetics, University of Cambridge, Cambridge, UK
,
Champakali Ayyub Tata Institute of Fundamental Research, Department of Biological Sciences, Colaba, Mumbai, India
,
Marien De Bruyne Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA
,
Anthony J. Dornan Institute of Biomedical Life Sciences – Division of Molecular Genetics, University of Glasgow, UK
,
Araceli Gomez-Hernandez Neurobiology Institute, UNAM, Campus UNAM Juriquilla, Querétaro, Mexico, USA
,
John Keane Department of Genetics, University of Cambridge, Cambridge, UK
,
James Killeen The Galton Laboratory, Department of Biology, University College London, UK
,
Susanne Kramer Universität Würzburg, Biozentrum, Würzburg, Germany
,
Mayur Madhavan Tata Institute of Fundamental Research, Department of Biological Sciences, Colaba, Mumbai, India
,
Helen Roe Department of Genetics, University of Leicester, Leicester, UK
,
Pradeep Dagadu Sherkhane Tata Institute of Fundamental Research, Department of Biological Sciences, Colaba, Mumbai, India
,
Khalid Siddiqi Tata Institute of Fundamental Research, Department of Biological Sciences, Colaba, Mumbai, India
,
Elizabeth Silva Department of Genetics, University of Cambridge, Cambridge, UK
,
John R. Carlson Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA
,
Stephen F. Goodwin Institute of Biomedical Life Sciences – Division of Molecular Genetics, University of Glasgow, UK
,
Martin Heisenberg Universität Würzburg, Biozentrum, Würzburg, Germany
,
Kits Krishnan Tata Institute of Fundamental Research, Department of Biological Sciences, Colaba, Mumbai, India
,
Charalambos P. Kyriacou Department of Genetics, University of Leicester, Leicester, UK
,
Linda Partridge The Galton Laboratory, Department of Biology, University College London, UK
,
Juan Riesgo-escovar Neurobiology Institute, UNAM, Campus UNAM Juriquilla, Querétaro, Mexico, USA
,
Veronica Rodrigues Tata Institute of Fundamental Research, Department of Biological Sciences, Colaba, Mumbai, India
,
Tim Tully Beckman Neuroscience, CenterCold Spring Harbor Laboratory, Cold Spring Harbor, New YorkUSA
&
Cahir J. O'Kane Tata Institute of Fundamental Research, Department of Biological Sciences, Colaba, Mumbai, India
 show all
Pages 57-85 | Received 19 Jan 2005, Accepted 24 Apr 2005, Published online: 11 Jul 2009
 
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Abstract

Most insertional mutagenesis screens of Drosophila performed to date have not used target chromosomes that have been checked for their suitability for phenotypic screens for viable phenotypes. To address this, we have generated a selection of stocks carrying either isogenized second chromosomes or isogenized third chromosomes, in a genetic background derived from a Canton-S wild-type strain. We have tested these stocks for a range of behavioral and other viable phenotypes. As expected, most lines are statistically indistinguishable from Canton-S in most phenotypes tested. The lines generated are now being used as target chromosomes in mutagenesis screens, and the characterization reported here will facilitate their use in screens of these lines for behavioral and other viable phenotypes.

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