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Journal of Neurogenetics Volume 19, 2005 - Issue 3-4
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SHORT COMMUNICATION

INTERLEUKIN-6 PROMOTER POLYMORPHISM AND LATE-ONSET ALZHEIMER's DISEASE IN THE FINNISH POPULATION

Anne M. Koivisto Department of Neurology, Kuopio University Hospital; Department of Neurology, Brain Research Unit, Clinical Research Centre/Mediteknia, University of Kuopio, FinlandCorrespondence[email protected]
,
Seppo Helisalmi Department of Neurology, Kuopio University Hospital; Department of Neurology, Brain Research Unit, Clinical Research Centre/Mediteknia, University of Kuopio, Finland
,
Jussi Pihlajamäki Department of Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
,
Leena Moilanen Department of Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
,
Johanna Kuusisto Department of Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
,
Markku Laakso Department of Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
,
Mikko Hiltunen Department of Neurology, Brain Research Unit, Clinical Research Centre/Mediteknia, University of Kuopio, Finland
,
Koivisto Keijo Department of Neurology, Central Hospital of South East Bothnia, Seinäjoki, Finland
,
Tuomo Hänninen Department of Neurology, Kuopio University Hospital; Department of Neurology, University of Kuopio, Finland
,
Eeva-Liisa Helkala Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland
,
Kari Kervinen Department of Medicine, Oulu University Hospital, Oulu, Finland
,
Y. Antero kesäniemi Department of Medicine, Oulu University Hospital, Oulu, Finland
&
Hilkka Soininen Department of Neurology, Kuopio University Hospital; Department of Neurology, Brain Research Unit, Clinical Research Centre/Mediteknia, University of Kuopio, Finland
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Pages 155-161 | Received 01 Aug 2005, Accepted 02 Dec 2005, Published online: 11 Jul 2009
 
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Abstract

Recently, the involvement of the inflammatory response in Alzheimer's disease (AD) has received considerable attention. The gene encoding for interleukin-6 (IL-6) is interesting since IL-6 has been reported not only to be involved in immune functions but also in AD. We investigated whether the IL-6-174 G/C polymorphism is associated with late onset AD (LOAD) in the Finnish subjects. The G allele was over-represented in ApoE4-LOAD patients but remained unimportant in all and in the ApoE E4 carriers. Interestingly, the G allele frequency was lower in our population in both AD patients and in controls compared to Southern European populations.

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