Expanding the representation of research from countries beyond Europe and North America is a goal for the Journal of Neurogenetics. This special issue is designed to highlight the flourishing discipline of Drosophila neurogenetics in South Korea. The aim is to provide readers with a snapshot of the diverse research areas that are at the cutting edge of the field.
Neurogenetics, the single-gene approach to study a wide range of neurobiological phenomena from the assembly of the nervous system, neurophysiology and circuit function to animal behaviors, has withstood early criticisms. Today, it stands as a fullyfledged and flourishing field.
Early research efforts were focused on neural development and behavior, for which many genetic tools were produced. As these tools became more sophisticated, they were utilized to delve deeper and provide better mechanistic insights. The evolution of Drosophila neurogenetics in South Korea remarkably mirrors this progression. In the 1990s, a vast array of mutant lines was generated to study neural development, which enabled researchers to extend their investigations beyond their original questions. This expansion of research horizons fueled the creation of new and more advanced genetic reagents. This cycle of innovating with old tools, which eventually leads to the development of new ones, is a perfect encapsulation of the spirit of neurogenetics.
This special issue is structured into four sections, beginning with the molecular mechanisms of neurodegeneration (Cha et al., Citation2022; Lee, Jo, et al., Citation2022), followed by the sensory modulation of sleep and arousal (Kim et al., Citation2022; Lee & Lim, Citation2022), then the use of machine learning to interrogate animal behaviors (Kim, An, et al., Citation2023; Kim, Kim, et al., Citation2023), and finally, nutrient sensors in feeding and non-feeding behaviors (Oh & Suh, Citation2022; Kim et al., Citation2023; Yoon et al., Citation2022). These studies offer exciting new findings as well as sketch out the future directions for the field in South Korea and around the world.
Acknowledgements
The authors thank all the contributors to this special issue and would like to note that two separate original research articles have been published in the previous year, which present highly relevant developments in South Korea on the topic of the gut-brain axis in Drosophila neurogenetic studies: Jang et al. (Citation2021) and Lim et al. (Citation2021).
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References
- Cha, S. J., Yoon, J. H., Han, Y. J., & Kim, K. (2022). Knockdown of glutathione Stransferase leads to mislocalization and accumulation of cabeza, a drosophila homolog of FUS, in the brain. Journal of Neurogenetics, 37(1-2), 20–24. doi:10.1080/01677063.2022.2149747
- Jang, S., Chen, J., Choi, J., Lim, S. Y., Song, H., Choi, H., Kwon, H. W., Choi, M. S., & Kwon, J. Y. (2021). Spatiotemporal organization of enteroendocrine peptide expression in Drosophila. Journal of Neurogenetics, 35(4), 387–398. doi:10.1080/01677063.2021.1989425
- Kim, G., An, J. H., Ha, S., & Kim, A. J. (2023). A deep learning analysis of Drosophila body kinematics during magnetically tethered flight. Journal of Neurogenetics, 37(1-2), 47–56. doi:10.1080/01677063.2023.2210682
- Kim, J., Kim, D., Jung, W., & Suh, G. S. B. (2023). Evaluation of mouse behavioral responses to nutritive versus nonnutritive sugar using a deep learning-based 3D real-time pose estimation system. Journal of Neurogenetics, 37(1-2) 78–83. doi:10.1080/01677063.2023.2174982
- Kim, M., Son, G. I., Cho, Y. H., Kim, G. H., Yoon, S. E., Kim, Y. J., Chung, J., Lee, E., & Park, J. J. (2022). Reduced branched-chain aminotransferase activity alleviates metabolic vulnerability caused by dim light exposure at night in Drosophila. Journal of Neurogenetics, 37(1-2), 25–35. doi:10.1080/01677063.2022.2144292
- Lee, H., & Lim, C. (2022). Circadian gating of light-induced arousal in Drosophila sleep. Journal of Neurogenetics, 37(1-2), 36–46. doi:10.1080/01677063.2022.2151596
- Lee, S., Jo, M., Kwon, Y., Jeon, Y. M., Kim, S., Lee, K. J., & Kim, H. J. (2022). PTK2 regulates tau-induced neurotoxicity via phosphorylation of p62 at Ser403. Journal of Neurogenetics, 37(1-2), 10–19. doi:10.1080/01677063.2022.2114471
- Lim, S. Y., You, H., Lee, J., Lee, J., Lee, Y., Lee, K. A., Kim, B., Lee, J. H., Jeong, J., Jang, S., Kim, B., Choi, H., Hwang, G., Choi, M. S., Yoon, S. E., Kwon, J. Y., Lee, W. J., Kim, Y. J., & Suh, G. S. B. (2021) Identification and characterization of GAL4 drivers that mark distinct cell types and regions in the Drosophila adult gut. Journal of Neurogenetics, 35:1, 33–44, DOI: 10.1080/01677063.2020.1853722
- Oh, Y., & Suh, G. S. B. (2023). Starvation-induced sleep suppression requires the Drosophila brain nutrient sensor. Journal of Neurogenetics, 37(1-2), 70–77.
- Suh, G. S. B., Yu, K., Kim, Y. J., Oh, Y., & Park, J. J. (2022). History of Drosophila neurogenetic research in South Korea. Journal of Neurogenetics, 37(1-2), 3–9. doi:10.1080/01677063.2022.2115040
- Yoon, S., Shin, M., & Shim, J. (2022). Inter-organ regulation by the brain in Drosophila development and physiology. Journal of Neurogenetics, 37(1-2), 57–69. doi:10.1080/01677063.2022.2137162