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Experimental Lung Research Volume 32, 2006 - Issue 1-2
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A PEPTIDE WITH ANTI-TRANSGLUTAMINASE ACTIVITY DECREASES LIPOPOLYSACCHARIDE-INDUCED LUNG INFLAMMATION IN MICE

Gee Young Suh Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
,
Hyoung Suk Ham Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
,
Shin-Hye Lee Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
,
Jae Chul Choi Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
,
Won-Jung Koh Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
,
Soo-Youl Kim Department of Neuroscience, Weill Medical College of Cornell University and Burke Medical Research Institute, Ithaca, New York, USA
,
Jongmin Lee Department of Neuroscience, Weill Medical College of Cornell University and Burke Medical Research Institute, Ithaca, New York, USA
,
Joungho Han Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
,
Hong Pyo Kim Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, USA
,
Augustine M. K. Choi Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, USA
&
O Jung Kwon Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaCorrespondence[email protected]
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Pages 43-53 | Received 27 Jun 2005, Accepted 16 Feb 2005, Published online: 02 Jul 2009
 
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Abstract

Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine mRNA expression in the lungs of LPS (25 mg/kg)-treated mice (P < .05). It also showed a tendency for decreased tumor necrosis factor (TNF)-α–immunoreactive protein in lung homogenates and significantly decreased TNF-α–immunoreactive protein in the serum of LPS-injected mice (P < .05). These results indicate that TGase may be a new therapeutic target in LPS-induced lung inflammation.

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