Combination of cardiac color Doppler ultrasound, serum MR-ProANP and NT-ProBNP forecasted hypertensive LVH and LFH

ABSTRACT

To analyze the value of the combined test of the cardiac color Doppler ultrasound, the serum middle receptor pro-atrial natriuretic peptide (MR-ProANP) and the N-terminal pro-brain natriuretic peptide (NT-ProBNP) in forecasting the hypertensive left ventricular hypertrophy (LVH) and left heart failure (LHF). All patients were subjected to cardiac color Doppler ultrasound examination to obtain left atrium volume index (LAVI), left ventricular end-diastolic diameter (LVEDD), early-diastolic peak flow velocity (E), early-diastolic mean flow velocity (e’), early-diastolic peak flow velocity/early-diastolic mean flow velocity (E/e’) and left ventricular ejection fraction (LVEF). Biomarkers were performed to obtain serum MR-ProANP and NT-ProBNP concentrations, and statistical analysis was performed. The LVEF was obviously lower than that in the control group (P<0.01). The area under the receiver operating characteristic (ROC) curve (AUC) values of LVEF, E/e’, serum MR-ProANP and NT-ProBNP alone were in the range of 0.7–0.8. The AUC, sensitivity and specificity of LVEF and E/e’ combined with MR-ProANP and NT-ProBNP to diagnose hypertensive LVH and LHF were 0.892, 89.14% and 78.21%, which were higher than those of single diagnosis. In the heart failure group, LVEF was negatively correlated with serum MR-ProANP and NT-ProBNP concentrations (P<0.05), and E/e’ was positively correlated with serum MR-ProANP and NT-ProBNP concentrations (P<0.05). Pump function and ventricular remodeling in patients with hypertensive LVH and LHF are closely related to serum MR-ProANP and NT-ProBNP levels. Combination of the two testing can improve the prediction and diagnostic efficacy of LHF.

KEYWORDS:

• cardiac color Doppler ultrasound
• MR-ProANP
• NT-ProBNP
• hypertensive LVH
• LHF

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data sharing agreement

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Additional information

Funding

The research was funded by National Administration of Traditional Chinese Medicine (Grant number: No.JDZX2015218).

Notes on contributors

Jian Jiang

Jian Jiang, visiting staff, master, has rich experience in ultrasound diagnosis, and cardiac ultrasound is the main research direction.

Min Hu

Min Hu, visiting staff, master, has been engaged in ultrasound diagnosis for 12 years, especially good at cardiac ultrasound diagnosis.

Qu Wang

Qu Wang, visiting staff, master, has been engaged in ultrasound diagnosis for 12 years, especially good at cardiac ultrasound diagnosis.

Yu Kang

Yu Kang, protomedicus, doctor, has been engaged in ultrasound diagnosis for nearly 30 years. He is especially good at cardiac ultrasound diagnosis, and has published 5 articles related to ultrasound in the core journal of Peking University in China.