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British Journal of Neurosurgery Volume 22, 2008 - Issue sup1: Proceedings from Pedunculopontine Nucleus Meeting
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Original Article

Pedunculopontine nucleus stimulation for people with Parkinson's disease? A clinical perspective

Ralph Gregory Neuroscience Unit, John Radcliffe Hospital, Oxford, UKCorrespondence[email protected]
Pages S13-S15 | Published online: 06 Jul 2009
 
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Abstract

Subthalamic deep brain stimulation is now well established as a treatment for the dopaminergic motor symptoms of Parkinson's disease. It has little effect on postural instability and “on-state” gait freezing. Animal experiments and early human pilot studies suggest that Pedunculopontine nucleus stimulation may alleviate these phenomenon, consistent with the hypothesis that these disabling symptoms are secondary to degeneration in non-dopaminergic pathways.

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