Wireless phone use and adult meningioma risk: a systematic review and Meta-analysis

Abstract

Introduction: Several studies explored the effects of exposure to radiofrequency-electromagnetic field (RF-EMF) and extremely low frequency (ELF) EMF emitted from mobile phones on meningioma among adults. However, the results could not reach an agreement. This meta-analysis was conducted to confirm the relationship between adult meningioma risk and the use of a wireless phone. Methods: Pertinent studies were identified by searching PubMed and Embase up to August 2018. The random- or fixed-effects model was used to combine the results depending on the heterogeneity of the analysis. The publication bias was evaluated using Egger’s regression asymmetry test. The subgroup analysis was performed by time since the first use of wireless phone and laterality (ipsilateral/contralateral). Results: Eight studies were enrolled in this meta-analysis. The pooled results suggested that the ever use of wireless phone led to a borderline decreased adult meningioma risk [odds ratio (OR) 0.90; 95% confidence interval (CI) 0.83–0.99] with no heterogeneity (I² = 5.3%; p = 0.391). A decreased risk of meningioma was seen in short-term (OR = 0.85; 95% CI = 0.77–0.94) users. Neither decreased nor increased risk of meningioma was observed in mid-term (OR = 0.93, 95% CI = 0.75–1.16) and long-term (OR = 1.05, 95% CI = 0.93–1.19) users. Neither ipsilateral (OR = 1.05, 95% CI = 0.90–1.22) nor contralateral (OR = 0.86, 95% CI = 0.62–1.18) wireless phone use was associated with the risk of meningioma. Conclusions: This meta-analysis suggested a relationship between decreased meningioma risk and wireless phone use. However, the findings need further validation.

Keywords:

• Wireless phone use
• cell phone
• mobile phone
• meningioma
• meta-analysis

Acknowledgments

We would like to thank Mr. Xie Tao for figure editing and Lan Jiaying for submitting the article. This work was supported by Natural Science Foundation of Guangdong Province (No. 2018A0303130236), The Project of Traditional Chinese Medicine Bureau of Guangdong Provincial (No.20202069), the Pearl River S & T Nova Program of Guangzhou (No.201806010025) and the Youth Pilot Project of Chinese Society of Traditional Chinese Medicine (CACM-2018-QNRC2-C09).

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by Natural Science Foundation of Guangdong Province [2018A0303130236].