The association between hematologic parameters and intracranial injuries in pediatric patients with traumatic brain injury

ABSTRACT

Objective

Analyzing the association between hematologic parameters and abnormal cranial computerized tomography (CT) findings after head trauma.

Material and methods

A total of 287 children with isolated traumatic brain injury (TBI) were divided into the ‘normal’ (NG), ‘linear fracture’ (LFG) and ‘intraparenchymal injury’ groups (IPG) based on head CT findings. Demographical/clinical data and laboratory results were obtained from medical records.

Results

The neutrophil-lymphocyte ratio was markedly higher in the LFG (p = 0.010 and p = 0.016, respectively) and IPG (p = 0.004 and p < 0.001, respectively) compared with NG. Lower lymphocyte-monocyte ratio (p = 0.044) and higher red cell distribution width-platelet ratio (RPR) (p = 0.030) were associated with intraparenchymal injuries. Patients requiring neurosurgical intervention had higher neutrophil-lymphocyte ratio (p = 0.026) and RPR values (p = 0.031) and lower platelet counts (p = 0.035). Lower levels of erythrocytes (p = 0.005), hemoglobin (p = 0.003) and hematocrit (p = 0.002) were associated with severe TBI and unfavorable outcome (p = 0.012, p = 0.004 and p = 0.006, respectively).                          

Conclusions

Hematologic parameters are useful in predicting the presence of abnormal cranial CT findings in children with TBI in association with injury severity; surgery need and clinical outcome.

KEYWORDS:

• Glasgow coma score
• hematologic markers
• neurosurgery
• outcome
• pediatric patients
• traumatic brain injury

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.