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Current Eye Research Volume 33, 2008 - Issue 1
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Research Article

Effect of Retinol Palmitate Eye Drops on Experimental Keratoconjunctival Epithelial Damage Induced byn-Heptanol in Rabbit

Hiroshi Toshida Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
,
Akito Odaka Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan; Pharmaceutical Research Laboratories No. 1, Pharmaceutical Products Division, Lion Corporation, Kanagawa, Japan
,
Daisuke Koike Pharmaceutical Research Laboratories No. 1, Pharmaceutical Products Division, Lion Corporation, Kanagawa, Japan
&
Akira Murakami Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
Pages 13-18 | Received 08 Apr 2007, Accepted 19 Nov 2007, Published online: 02 Jul 2009
 
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Abstract

Purpose: To investigate ability of vitamin A (VA, retinol palmitate) to promote wound healing after injury in rabbit eye. Methods: After keratoconjunctival injury by 20 μ L of n-heptanol, VA eye drops at 500, 1000, or 1500 IU/mL were started 6 times a day for 11 days. Fluorescein and rose bengal staining and histological analysis were performed. Results: Fluorescein staining was significantly reduced by 1000 and 1500 IU/mL of VA and rose bengal staining by all concentrations. Histological examination revealed acceleration of wound healing after 7 days (1500 IU/mL). Conclusions: VA may be useful in treatment of keratoconjunctival injury.

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