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Current Eye Research Volume 34, 2009 - Issue 5
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Original

Characteristics of Ethylnitrosourea-Induced Cataracts

Min-Jung Lee Division of Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea 21 Project, Oral Science Research Center, College of Dentistry, Yonsei Center of Biotechnology, Yonsei University, Seoul, Korea
,
Jae-Young Kim Department of Biochemistry, School of Dentistry, Brain Korea 21 Project, IHBR, Kyungpook National University, Daegu, Korea
,
Yeun-Jung Kim Division of Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea 21 Project, Oral Science Research Center, College of Dentistry, Yonsei Center of Biotechnology, Yonsei University, Seoul, Korea
,
Jae-Woo Cho Division of Inhalation Toxicology, Korea Institute of Toxicology, Korea Research Institute of Chemical Technology, Daejeon, Korea
,
Kyu-Hyuk Cho Division of Inhalation Toxicology, Korea Institute of Toxicology, Korea Research Institute of Chemical Technology, Daejeon, Korea
,
Chang-Woo Song Division of Inhalation Toxicology, Korea Institute of Toxicology, Korea Research Institute of Chemical Technology, Daejeon, Korea
&
Han-Sung Jung Division of Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea 21 Project, Oral Science Research Center, College of Dentistry, Yonsei Center of Biotechnology, Yonsei University, Seoul, Korea
 show all
Pages 360-368 | Received 21 Dec 2008, Accepted 19 Feb 2009, Published online: 02 Jul 2009
 
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Abstract

Purpose: This study analyzed genes associated with the morphology and regulation of ethylnitrosourea (ENU)-induced cataract mouse. Materials and Methods: Immunohistochemistry analysis using anti-crystallins and PCNA antibody revealed that the localization pattern of these specific markers differed between the cataractous and wild-type lens epithelium. Two-dimensional electrophoresis and microarray techniques were used to identify the proteins and genes related to ENU-induced cataract. Results: A novel ENU-induced mutation in the mouse led to nuclear and cortical opacity of the eye lens at 5 weeks postnatal. This cataract phenotype was similar to that of the zonular-pulverulent type of human cataract. Crystallin proteins and gap-junction genes have relations to the formation of cataract. Conclusions: Together, the results suggest that various proteins affect the formation and specific phenotypes of ENU-induced cataract mouse.

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