Advanced search
Publication Cover
Journal of Asthma Volume 43, 2006 - Issue 3
Submit an article Journal homepage
53
Views
7
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

ADA Polymorphisms and Asthma: A Study in the Chinese Han Population

Y. Liu Department of Respiratory Disease, Xijing Hospital, Shaanxi Province, People's Republic of China
,
P. Saccucci Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy
,
H. Qi Department of Respiratory Disease, Xijing Hospital, Shaanxi Province, People's Republic of China
,
H. C. Wu Department of Respiratory Disease, Xijing Hospital, Shaanxi Province, People's Republic of China
,
F. Zhao Department of Respiratory Disease, Xijing Hospital, Shaanxi Province, People's Republic of China
,
Y. Dai Department of Respiratory Disease, Xijing Hospital, Shaanxi Province, People's Republic of China
,
N. Bottini Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
&
F. Gloria-Bottini Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy
 show all
Pages 203-206 | Published online: 02 Jul 2009
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

We have studied a sample of 120 asthmatic patients and 116 healthy control subjects from the Chinese Han population. Three polymorphic sites: ADA1, ADA2, and ADA6, within the ADA gene have been examined. The proportion of carriers of *2 allele at locus ADA1 is drastically reduced in asthmatics as compared to controls. There is an epistatic interaction of ADA2 on the ADA1 site characterized by a suppressive effect by the *2 allele of ADA2 on the protective effect exerted by the *2 allele of ADA1 site on susceptibility to asthma. Our data suggest the presence of some DNA sequences influencing the susceptibility to asthma are located in the area between ADA1 and ADA2 sites.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,078.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.