Early life environment and developmental immunotoxicity in inflammatory dysfunction and disease

Abstract

Components of the innate immune system such as macrophages and dendritic cells are instrumental in determining the fate of immune responses and are, also, among the most sensitive targets of early life environmental alterations including developmental immunotoxicity (DIT). DIT can impede innate immune cell maturation, disrupt tissue microenvironment, alter immune responses to infectious challenges, and disrupt regulatory responses. Dysregulation of inflammation, such as that observed with DIT, has been linked with an increased risk of chronic inflammatory diseases in both children and adults. In this review, we discuss the relationship between early-life risk factors for innate immune modulation and promotion of dysregulated inflammation associated with chronic inflammatory disease. The health risks from DIT-associated inflammation may extend beyond primary immune dysfunction to include an elevated risk of several later-life, inflammatory-mediated diseases that target a wide range of physiological systems and organs. For this reason, determination of innate immune status should be an integral part of drug and chemical safety evaluation.

Keywords:

• developmental immunotoxicity
• inflammation
• TLRs
• risk factors
• macrophages
• dendritic cells
• innate immunity

Acknowledgments

The authors thank Janice Dietert for her editorial suggestions. The research of CAL on innate immune cells and toll-like receptors is supported by NIH (AI076588, AI076588-S1).