Raynaud’s phenomenon and nailfold capillaroscopic findings in anorexia nervosa

Abstract

Background: Peripheral vascular abnormalities caused by a dysregulation between peripheral vasoconstriction and vasodilatation, clinically appearing with Raynaud’s phenomenon, have been described in anorexia nervosa but specific characteristics of microcirculation in anorexic patients have not yet been studied.

Methods: We performed nailfold videocapillaroscopy to assess microcirculatory alteration in anorexic patients and found three different patterns: normal, aspecific and early scleroderma pattern. We also evaluated several laboratory and clinical parameters to better assess our capillaroscopic findings.

Results: None of the clinical parameters examined correlated with specific capillaroscopic findings. An increased risk of autoimmune diseases in eating disorder patients has been described. Our results evidenced an association between early scleroderma capillaroscopic pattern and Raynaud’s phenomenon that occurs in anorexia nervosa patients, whereas no significant association was found between all three capillaroscopic patterns and the presence of autoantibodies, as well as ESR and CRP values.

Conclusions: Our study reveals that patients with AN suffering from RP exhibit NVC findings typical of connective tissue diseases.

Keywords:

• Anorexia nervosa
• capillaroscopy
• Raynaud phenomenon
• microcirculation
• translational medicine

Transparency

Declaration of funding

Declaration of financial/other relationships

M.D.M., M.M.S. and L.G. have disclosed that they have no significant relationships with or financial interests in any commercial companies related to this study or article.