Interval analysis of blood filtration efficacy in novel device for autotransfusion in postpartum hemorrhage

Abstract

Postpartum haemorrhage (PPH), the leading cause of maternal mortality, is particularly problematic in low resource settings where access to safe blood supplies and definitive medical treatment is limited. We describe the continued development of an autotransfusion device designed to treat PPH by collection, filtration and infusion of maternal blood. Previous study has demonstrated that the device effectively moves blood through a filtration apparatus and removes up to 97% of aerobic bacteria but had poor anaerobic bacteria reduction. In this study, we investigate the filtration efficacy of the device using configurations comprised of three different leukocyte depletion filter designs: the Pall Leukoguard RS leukocyte reduction filter (PLRF), the Haemonetics BPF4™ (BPF4) leukocyte reduction filter, and the Haemonetics SCRC Leukotrap® (SCRC) filter. All configurations performed well with reductions ranging from 49 to 98%. Configurations containing 2 Haemonetics SCRC Leukotrap^®filters (configuration 5 and 6) consistently reduced anaerobic bacteria by at least 73%. These results indicate that utilising a combination of SCRC and PLRF filters confers a high level of microbial filtration with improved removal of anaerobic organisms.

Keywords:

• Postpartum haemorrhage
• microbial filtration
• obstetrics
• medical device
• global health

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This project has been funded by the University of Illinois at Chicago Chancellor's Discovery Fund for Multidisciplinary Research and the University of Illinois at Chicago Chancellor's Innovation Fund Proof-of-Concept Awards Programme.