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Hemoglobin
international journal for hemoglobin research
Volume 31, 2007 - Issue 4
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Short Communication

Hb Hekinan in a Taiwanese Subject: A G→T Substitution at Codon 27 of the α1-Globin Gene Abolishes an HaeIII Site

Hung-Chang Shih Department of Laboratory Medicine, China Medical University Hospital, Taichung, Taiwan; Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
,
Mu-Chin Shih Department of Laboratory Medicine, China Medical University Hospital, Taichung, Taiwan
,
Yu-Chang Chang Department of Laboratory Medicine, China Medical University Hospital, Taichung, Taiwan
,
Ching-Tien Peng Department of Laboratory Medicine, China Medical University Hospital, Taichung, Taiwan; Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan
,
Tien-Jye Chang Department of Veterinary Medicine, National Chung Hsing University, Taichung, TaiwanCorrespondence[email protected]
&
Jan-Gowth Chang Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanCorrespondence[email protected]
Pages 495-498 | Received 28 Feb 2007, Accepted 06 Jun 2007, Published online: 07 Jul 2009
 
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Abstract

We recently observed a heterozygote for Hb Hekinan in a Taiwanese subject. The molecular lesion of Hb Hekinan is a substitution of G→T at codon 27 of the α1-globin gene, which abolishes an HaeIII restriction enzyme site. Hb Hekinan [α27(B8)Glu→Asp, GAG→GAC (α2)] has not been found in Taiwan. This variant can be detected by high performance liquid chromatography (HPLC) but not by capillary or cellulose electrophoresis.

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