Application of Ion Exchange Resin in Floating Drug Delivery System

Abstract

The purpose of this study was to explore the application of low-density ion exchange resin (IER) Tulsion® 344, for floating drug delivery system (FDDS), and study the effect of its particle size on rate of complexation, water uptake, drug release, and in situ complex formation. Batch method was used for the preparation of complexes, which were characterized by physical methods. Tablet containing resin with high degree of crosslinking showed buoyancy lag time (BLT) of 5–8 min. Decreasing the particle size of resin showed decrease in water uptake and drug release, with no significant effect on the rate of complexation and in situ complex formation for both preformed complexes (PCs) and physical mixtures (PMs). Thus, low-density and high degree of crosslinking of resin and water uptake may be the governing factor for controlling the initial release of tablet containing PMs but not in situ complex formation. However, further sustained release may be due to in situ complex formation.

Keywords:

• ion exchange resin
• floating system
• in situ complexes

ACKNOWLEDGMENTS

Abhijeet A. Upadhye is thankful to AICTE, New Delhi, India for financial support in the form of JRF. Anshuman A. Ambike is thankful to CSIR, New Delhi, India for the financial support in terms of CSIR-SRF. The authors are thankful to THERMAX Ltd., Chemical Division, Pune, India for financial support and gift samples of Tulsion® 344.