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Cancer Investigation Volume 25, 2007 - Issue 1
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BRIEF CLINICAL REPORT

Hepatitis B Virus and Intrahepatic Cholangiocarcinoma

Nikolaos K. Gatselis Department of Medicine (Academic Liver Unit & Research Lab of Internal Medicine), Medical School, University of Thessaly, ThessalyGreece
, M.D., Ph.D.,
Konstantinos Tepetes Department of Surgery, Medical School, University of Thessaly, Thessaly, Greece
, M.D., Ph.D.,
Argirios Loukopoulos Department of Medicine (Academic Liver Unit & Research Lab of Internal Medicine), Medical School, University of Thessaly, ThessalyGreece
, M.D.,
Katerina Vasiou Department of Radiology, Medical School, University of Thessaly, Thessaly, Greece
, M.D., Ph.D.,
Athanasios Zafiriou Department of Medicine (Academic Liver Unit & Research Lab of Internal Medicine), Medical School, University of Thessaly, ThessalyGreece
, M.D.,
Chrisoula Gioti Department of Medicine (Academic Liver Unit & Research Lab of Internal Medicine), Medical School, University of Thessaly, ThessalyGreece
, M.D. &
Georgios N. Dalekos Department of Medicine (Academic Liver Unit & Research Lab of Internal Medicine), Medical School, University of Thessaly, ThessalyGreece
, M.D., Ph.D. show all
Pages 55-58 | Published online: 11 Jun 2009
 
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Abstract

Intrahepatic cholangiocarcinoma (ICC) is a rare type of primary liver cancer that arises from intrahepatic bile ducts. Its etiopathogenesis has been considered to be independent of the presence of chronic viral hepatitis infections or cirrhosis. These factors, particularly the hepatitis C virus, have been reported to play a role in the development of cholangiocarcinoma in a few studies, with inconclusive results. We report 2 cases of ICC that presented with a background of hepatitis B virus (HBV) infection and discuss the possible pathophysiological relationships between ICC and HBV infection, with an emphasis on the x gene of HBV.

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