Combination Treatment of Human Umbilical Cord Matrix Stem Cell-Based Interferon-Beta Gene Therapy and 5-Fluorouracil Significantly Reduces Growth of Metastatic Human Breast Cancer in SCID Mouse Lungs

Abstract

Umbilical cord matrix stem (UCMS) cells that were engineered to express interferon-beta (IFN-β) were transplanted weekly for three weeks into MDA 231 breast cancer xenografts bearing SCID mice in combination with 5-fluorouracil (5-FU). The UCMS cells were found within lung tumors but not in other tissues. Although both treatments significantly reduced MDA 231 tumor area in the SCID mouse lungs, the combined treatment resulted in a greater reduction in tumor area than by either treatment used alone. These results indicate that a combination treatment of UCMS-IFN-β cells and 5-FU is a potentially effective therapeutic procedure for breast cancer.

Keywords:

• Interferon-beta
• Lung tumors
• UCMS cells
• MDA-231 breast carcinoma cells
• 5-fluorouracil