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COMMENTARY

The Emperor's New Clothes or the Current Practice of Clinical Trials for Multiple Myeloma in the USA

Pages 445-447 | Published online: 11 Jun 2009
 

Abstract

Phase III clinical trials help define standard therapies by comparing the outcomes of a new (experimental) treatment arm to the best established (control) arm. Superior outcomes should only be defined in measures of patient benefit. Two recent trials for upfront therapy of patients with multiple myeloma (ECOG E1A00 and E4A03) failed to conform to traditional Phase III trial design. Consequently they failed to provide any useful scientific data.

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