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Cancer Investigation Volume 26, 2008 - Issue 10
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ORIGINAL ARTICLESCellular and Molecular Biology

Expression of CD147 Mediates Tumor Cells Invasion and Multidrug Resistance in Hepatocellular Carcinoma

Li Jia Department of Biochemistry, Institute of Glycobiology, Dalian Medical University, Dalian, China; College of Laboratory Medicine, Dalian Medical University, Dalian, China
,
Henggui Xu College of Laboratory Medicine, Dalian Medical University, Dalian, China
,
Yongfu Zhao Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, China
,
Lili Jiang Department of Foreign Language, Dalian Medical University, Dalian, China
,
Jingda Yu College of Laboratory Medicine, Dalian Medical University, Dalian, China
&
Jianing Zhang Department of Biochemistry, Institute of Glycobiology, Dalian Medical University, Dalian, China
Pages 977-983 | Published online: 11 Jun 2009
 
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Abstract

Multidrug resistant (MDR) tumor cells over-expressing P-glycoprotein exhibit variation in invasive behavior. To investigate the mechanisms, we analyzed the expression of CD147. The results showed that CD147 expression was increased in HepG2/Adr cells, as compared to HepG2 cells. The MDR cells produced more MMP11 and MDR1, which promoted HepG2/Adr cells invasion and increased resistance to chemotherapeutic drugs. On the other hand, CD147 silencing in HepG2/Adr cells by RNAi led to the opposite effect. Treatment of tumor cells with U-0126, an inhibitor of MAPK/Erk, also down-regulated MMP11 and MDR1 expression. Thus, CD147 may functionally mediate tumor cells invasion and MDR.

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