Multidrug Resistance Mediated by MRP1 Gene Overexpression in Breast Cancer Patients

Abstract

Multidrug resistance (MDR) is a serious handicap towards the effective treatment of breast cancer patients. One of the most prevalent MDR mechanisms is through the overexpression of genes coding the proteins called Multidrug Resistance-associated Proteins (MRPs). The aim of this study was to investigate the expression of MRP1 in tumor tissues from breast cancer patients. In this study, a semi-quantitative RT-PCR approach was utilized. Our results suggest that MRP1 overexpression can mediate MDR in patients. Pre-evaluation of the level of such MDR mediators before chemotherapy can increase the efficacy of the treatment.

Keywords:

• Multidrug resistance
• MDR
• MRP1
• Breast cancer
• Chemotherapy
• MRP Family

ABBREVIATIONS
FFPE	=	Formalin fixed parafin embedded
GSH	=	glutathione
MDR	=	Multidrug resistance
MRP1	=	Multidrug Resistance-associated Protein-1

ABBREVIATIONS
FFPE	=	Formalin fixed parafin embedded
GSH	=	glutathione
MDR	=	Multidrug resistance
MRP1	=	Multidrug Resistance-associated Protein-1