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Cancer Investigation Volume 27, 2009 - Issue 2
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ORIGINAL ARTICLES Cellular and Molecular Biology

Antitumor Properties of Gymnosperma Glutinosum Leaf Extracts

R. Gomez-Flores Department of Microbiology and Immunology, Biological Sciences College, Autonomous University of Nuevo Leon, San Nicolás de los Garza, N.L., Mexico
,
L. Verástegui-Rodríguez Department of Microbiology and Immunology, Biological Sciences College, Autonomous University of Nuevo Leon, San Nicolás de los Garza, N.L., Mexico
,
R. Quintanilla-Licea Department of Chemistry, Biological Sciences College, Autonomous University of Nuevo Leon, San Nicolas de los Garza, N.L., Mexico
,
P. Tamez-Guerra Department of Microbiology and Immunology, Biological Sciences College, Autonomous University of Nuevo Leon, San Nicolás de los Garza, N.L., Mexico
,
E. Monreal-Cuevas Department of Microbiology and Immunology, Biological Sciences College, Autonomous University of Nuevo Leon, San Nicolás de los Garza, N.L., Mexico
,
R. Tamez-Guerra Department of Microbiology and Immunology, Biological Sciences College, Autonomous University of Nuevo Leon, San Nicolás de los Garza, N.L., Mexico
&
C. Rodríguez-Padilla Department of Microbiology and Immunology, Biological Sciences College, Autonomous University of Nuevo Leon, San Nicolás de los Garza, N.L., Mexico
 show all
Pages 149-155 | Published online: 11 Jun 2009
 
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Abstract

The present study was undertaken to validate the antitumor potential of Gymnosperma glutinosum from regional people's account, using the in vitro and in vivo L5178Y-R lymphoma murine model. Non-polar G. glutinosum crude extracts were tested on L5178Y-R cells. We found significant (p < 0.05) cytotoxic activity (up to 40%) of the hexane extract, which was further fractioned; fraction 1 (F1) was then observed to produce up to 51% apoptosis-mediated L5178Y-R cytotoxicity in vitro at concentrations lower than 0.98 μ g/ml, and possess significant in vivo antitumor activity. This study may support further evaluation of active F1 in clinical trials.

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