Polymorphism in Cytochrome P4501A1 is Significantly Associated with Head and Neck Cancer Risk

Abstract

A case control study was undertaken to investigate the association of polymorphisms in cytochrome P4501A1 (CYP1A1) with squamous cell carcinoma of head and neck (HNSCC) in North Indian population. The variant genotypes of CYP1A1*2A and CYP1A1*2C were found to be overrepresented in cases when compared to controls. The HNSCC risk also increased several folds in cases with combination of variant genotypes of CYP1A1*2A or CYP1A1*2C with null genotype of glutathione-S-transferase M1 (GSTM1), a phase II enzyme, particularly in cases who were tobacco users (smokers and tobacco chewers), demonstrating the role of gene–gene and gene–environment interactions in the development of HNSCC.

Keywords:

• Head and neck cancer
• Cytochrome P450 1A1
• Polymorphism
• Haplotypes
• Risk