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Cancer Investigation Volume 36, 2018 - Issue 2
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Articles

Biomarkers in Recurrent Grade III Glioma Patients Treated with Bevacizumab and Irinotecan

Anders ToftDepartment of Radiation Biology, The Finsen Center, Rigshospitalet, Copenhagen, DenmarkCorrespondence[email protected]
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Thomas UrupDepartment of Radiation Biology, The Finsen Center, Rigshospitalet, Copenhagen, Denmark;Department of Oncology, The Finsen Center, Rigshospitalet, Copenhagen, DenmarkView further author information
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Ib Jarle ChristensenDepartment of Surgical Gastroenterology, Hvidovre Hospital, Hvidovre, DenmarkView further author information
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Signe Regner MichaelsenDepartment of Radiation Biology, The Finsen Center, Rigshospitalet, Copenhagen, DenmarkView further author information
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Babloo LukramDepartment of Pathology, Center of Diagnostic Investigation, Rigshospitalet, Copenhagen, DenmarkView further author information
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Kirsten GrunnetDepartment of Radiation Biology, The Finsen Center, Rigshospitalet, Copenhagen, Denmark;Department of Oncology, The Finsen Center, Rigshospitalet, Copenhagen, DenmarkView further author information
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Michael KosteljanetzDepartment of Neurosurgery, Neuroscience Centre, Rigshospitalet, Copenhagen, DenmarkView further author information
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Vibeke Andrée LarsenDepartment of Radiology, Center of Diagnostic Investigation, Rigshospitalet, Copenhagen, DenmarkView further author information
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Ulrik LassenDepartment of Radiation Biology, The Finsen Center, Rigshospitalet, Copenhagen, Denmark;Department of Oncology, The Finsen Center, Rigshospitalet, Copenhagen, Denmark;Phase I Unit, The Finsen Center, Rigshospitalet, Copenhagen, DenmarkView further author information
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Helle BroholmDepartment of Pathology, Center of Diagnostic Investigation, Rigshospitalet, Copenhagen, DenmarkView further author information
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Hans Skovgaard PoulsenDepartment of Radiation Biology, The Finsen Center, Rigshospitalet, Copenhagen, Denmark;Department of Oncology, The Finsen Center, Rigshospitalet, Copenhagen, DenmarkView further author information
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Pages 165-174 | Received 07 Jan 2018, Accepted 17 Jan 2018, Published online: 02 Feb 2018
 
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ABSTRACT

Predictive biomarkers and prognostic models are required to identify recurrent grade III glioma patients who benefit from existing treatment. In this study of 62 recurrent grade III glioma patients, a range of clinical and paraclinical factors are tested for association with progression-free survival, overall survival, and response to bevacizumab and irinotecan therapy. Significant factors from univariate screening are included in multivariate analysis. Biomarkers previously advanced as predictive or prognostic in the first-line setting did not affect outcome in this patient cohort. Based on the optimized model for overall survival, comprising performance status and p53 expression, a prognostic index is established.

Declaration of interest

The authors report no declarations of interest.

Additional information

Funding

The Sejer Persson & Lis Klüver Persson Foundation and The Danish Cancer Society (R101-A6634-14-S7)

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