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Drying Technology
An International Journal
Volume 24, 2006 - Issue 3
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Original Articles

Powder Characteristics of Pantoprazole Delivery Systems Produced in Different Spray-Dryer Scales

R. P. Raffin Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre-RS, Brazil
,
S. S. Guterres Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre-RS, Brazil
,
A. R. Pohlmann IPT - Institute for Technological Research of the State of São Paulo, Laboratory of Processes Chemical and Particle Technolgy, Cidade Universitária, São Paulo, SP, Brazil
&
M. I. Ré IPT - Institute for Technological Research of the State of São Paulo, Chemistry Division, Laboratory of Particles Technology, Cidade Universitária, São Paulo-SP, BrazilCorrespondence[email protected]
Pages 339-348 | Published online: 06 Feb 2007
 
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ABSTRACT

The purpose of this study is to investigate the physical characteristics of pantoprazole-loaded enteric microparticles produced in different spray dryers and operational conditions. In all conditions tested it was possible to obtain powders that presented spherical shape microparticles, with mean sizes from 6.7 to 24.5 µm. The size was affected mainly by initial feed concentration (2.2 or 6.6% w/w). The integrity of microparticles affected surface area (24 to 113 m2/g)and drug release (71 to 98%). All powders presented very poor flow. The powder that presented higher release was produced with 6.6% solution and a rotating disc atomizer.

Notes

S.D., standard deviations for the mean diameter.

S.D., standard deviations for the mean diameter.

S.D., standard deviations for the mean diameter.

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