Interplay of vitamin D, vitamin B₁₂, homocysteine and bone mineral density in postmenopausal females

ABSTRACT

Osteoporosis is most common age related, multifactorial disease. The aim of the researchers were to discover the association between serum homocysteine, vitamin D, vitamin B₁₂ and bone mineral density in postmenopausal non-osteoporotic and osteoporotic females. In this cross- sectional study, 156 postmenopausal females between 50–70 years of age were recruited and divided into two groups, non-osteoporotic (n = 52) and osteoporotic (n = 104). There was significant negative correlation of homocysteine with vitamin D and B₁₂ in postmenopausal non-osteoporotic and homocysteine with vitamin B₁₂ in postmenopausal osteoporotic females. Serum homocysteine levels were predicted by vitamin D in postmenopausal non-osteoporotic and vitamin B₁₂ in postmenopausal osteoporotic females.

Disclosure statement

The authors declare that they have no conflict of interest.

Additional information

Funding

The research has been funded by grant from higher education commission, Islamabad, Pakistan.

Notes on contributors

Sundus Tariq

Sundus Tariq Conducted the research, collected the data and prepared the manuscript.

Saba Tariq

Saba Tariq Carried out the literature search, helped in analyzing the data and preparation of manuscript.

Khalid Parvez Lone

Khalid Parvez Lone Supervised the research, helped in finalizing the manuscript.