Chronotherapy of hypertension: advantages of 48-h ambulatory blood pressure monitoring assessments in MAPEC and Hygia Chronotherapy Trial

ABSTRACT

The specific purpose of this communication is to summarize the relevant details of the methods utilized to conduct, analyze, and interpret the ambulatory blood pressure (BP) monitoring (ABPM)-obtained patient data in both MAPEC and Hygia Chronotherapy Trial, including details of the sampling requirements in terms of duration and frequency, proper calculation of ABPM-derived mean values, prognostic and therapeutic implications of BP dipping, and limitations of the 24 h BP mean as diagnostic/prognostic parameter still mistakenly recommended by some hypertension guidelines.

KEYWORDS:

• Ambulatory blood pressure monitoring
• sleep-time blood pressure
• bedtime hypertension chronotherapy
• cardiovascular risk
• Hygia Chronotherapy Trial
• MAPEC study
• Hygia Project
• dipper
• non-dipper
• extreme-dipper
• glaucoma
• abpm-effect

Disclosure statement

The authors report no conflicts of interest.