Intravitreal Brolucizumab for Chronic Central Serous Chorioretinopathy without Choroidal Neovascular Membrane – a Pilot Study

ABSTRACT

Purpose

To study intravitreal brolucizumab in the management of persistent macular fluid in chronic central serous chorioretinopathy (CSCR) without choroidal neovascular membrane (CNVM).

Methods

Retrospective case series which included eyes with chronic CSCR with persistent macular fluid for ≥ 3 months without CNVM. Intravitreal brolucizumab was administered in all eyes. Primary outcome measure was the resolution of intraretinal (IRF) and/or subretinal fluid (SRF) on OCT.

Results

Five eyes (four patients) with chronic CSCR were included. All eyes showed complete resolution of SRF 1 month following injection. Minimal residual IRF was present in two eyes. Best corrected visual acuity (BCVA) was stable in three eyes, and two eyes showed improvement. Central macular thickness (CMT) and subfoveal choroidal thickness (SFCT) showed reduction.

Conclusion

Intravitreal brolucizumab is effective in the rapid reduction of persistent macular fluid in chronic CSCR without CNVM. Long-term follow-up data are required to study recurrence and adverse effect profile.

KEYWORDS:

• Brolucizumab
• chronic
• complex CSCR
• CSCR
• persistent fluid

ABBREVIATIONS

CSCR	=	Central Serous Chorioretinopathy
PDT	=	Photodynamic Therapy
SMPLT	=	Subthreshold Micropulse Laser Therapy
CNVM	=	Choroidal Neovascular Membrane
VEGF	=	Vascular Endothelial Growth Factor
RPE	=	Retinal Pigment Epithelium
BCVA	=	Best Corrected Visual Acuity
IOP	=	Intraocular Pressure
OCT	=	Optical Coherence Tomography
OCTA	=	Optical Coherence Tomography Angiography
FFA	=	Fundus Fluorescein Angiography
ICGA	=	Indocyanine green Angiography
CMT	=	Central Macular Thickness
SFCT	=	Subfoveal Choroidal Thickness
RE	=	Right Eye
LE	=	Left Eye
SRF	=	Subretinal fluid
IRF	=	Intraretinal fluid

DISCLOSURE STATEMENT

No potential conflict of interest was reported by the author(s).

FINANCIAL SUPPORT

Hyderabad Eye Research Foundation.

Additional information

Funding

The work was supported by the Hyderabad Eye Research Foundation.