Efficacy of a Fixed-Dose Combination of Trandolapril-Verapamil in Obese Hypertensive Patients Resistant to Monotherapy

Abstract

This paper sought to determine if the fixed-dose combination of trandolapril and verapamil is effective in the treatment of hypertensive obese patients resistant to monotherapy. Thirty-six hypertensive obese patients uncontrolled by monotherapy were given the combination of trandolapril-verapamil (2/180 mg) for 12 weeks. Before and after taking the drug, they self-measured their blood pressure. Patients experienced a significant reduction of blood pressure (from 178 ± 18/100 ± 12 mm Hg to 135 ± 14/76 ± 7 mm Hg, p < 0.001). Eighty percent of patients reached therapeutic goals; one patient suffered from headaches and one had constipation. it was determined that the combination of trandolapril-verapamil is effective and safe for the management of hypertension in obese patients uncontrolled by monotherapy.

Keywords:

• uncontrolled hypertension
• obesity
• trandolapril
• verapamil
• combination therapy