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Pediatric Hematology and Oncology Volume 21, 2004 - Issue 6
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Research Article

A CASE OF ACUTE LYMPHOBLASTIC LEUKEMIA PRESENTING AS SEVER HYPERCALCEMIA

Paola Sabrina Buonuomo Pediatric Intensive Care Unit, Università Cattolica del Sacro Cuore, Policlinico “A. Gemelli,”, Rome, ItalyCorrespondence[email protected]
, MD,
Antonio Ruggiero Pediatric Oncology, Università Cattolica del Sacro Cuore, Policlinico “A. Gemelli,”, Rome, Italy
, MD,
Marco Piastra Pediatric Intensive Care Unit, Università Cattolica del Sacro Cuore, Policlinico “A. Gemelli,”, Rome, Italy
, MD,
Riccardo Riccardi Pediatric Oncology, Università Cattolica del Sacro Cuore, Policlinico “A. Gemelli,”, Rome, Italy
, MD,
Giancarlo Polidori Pediatric Intensive Care Unit, Università Cattolica del Sacro Cuore, Policlinico “A. Gemelli,”, Rome, Italy
, MD &
Antonio Chiaretti Pediatric Intensive Care Unit, Università Cattolica del Sacro Cuore, Policlinico “A. Gemelli,”, Rome, Italy
, MD
Pages 475-479 | Published online: 09 Jul 2009
 
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Abstract

A 9-year-old girl presented at the Pediatric Emergency Department with an acute onset of gastrointestinal symptoms due to hypercalcemia. Despite the absence of circulating blast, bone marrow biopsy was diagnostic of acute lymphoblastic leukemia. The hypercalcemia was initially treated with intravenous hydration and furosemide, and later on with bisphosphonates. However, the serum calcium levels normalized only after the beginning of specific chemotherapy. Hypercalcemia represents an emergency in children, and acute leukemia must be considered in its differential diagnosis, even when there are no circulating blasts.

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