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Brief Report

Vomiting in children and adolescents receiving intravenous pegaspargase: a retrospective study

, , , &
Received 30 Oct 2023, Accepted 24 Jan 2024, Published online: 07 Mar 2024
 

Abstract

Due to an evidence gap, the emetogenicity of intravenous (IV) pegaspargase was unable to be included in the clinical practice guideline classifying chemotherapy emetogenicity in pediatric patients. This single-center, retrospective chart review describes the proportion of pediatric patients who did not vomit during the acute phase (complete response; CR) after receiving IV pegaspargase and provides an emetogenicity classification using a preexisting framework. Of 44 patients who received IV pegaspargase between 2011 and 2020, 13 received a serotonin receptor antagonist plus dexamethasone or palonosetron alone and all experienced a CR. We, therefore, recommend classifying IV pegaspargase as moderately emetogenic.

Disclosure statement

The authors have no relevant conflicts of interest to report.

Funding

This research was funded in part through the NIH/NCI Cancer Center Support Grant P30 CA008748.

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